Recruitment of patients by city
Center First participant in Months accruing Participants accrued Accrual rate (per month)
2 Lausanne 07Jan2025 6 43 7.41
3 Chur 01Jan2025 6 34 5.67
4 Luzern 05Jan2025 6 37 6.31
5 Neuchâtel 02Jan2025 6 36 6.03
6 Fribourg 11Jan2025 6 29 5.12
7 Baden 03Jan2025 6 25 4.21
8 Aarau 01Jan2025 6 43 7.17
9 Bern 07Jan2025 6 37 6.38
10 Olten 01Jan2025 6 32 5.33
11 Sion 06Jan2025 6 26 4.46
12 Basel 07Jan2025 6 30 5.17
13 Berlin 23Jan2025 5 10 1.90
14 Verona 18Jan2025 5 15 2.76
15 Zurich 07Jan2025 6 41 7.07
16 Lugano 04Jan2025 6 29 4.92
17 St. Gallen 01Jan2025 6 37 6.17
18 Solothurn 03Jan2025 6 25 4.21
19 Paris 07Feb2025 5 4 0.84
20 Amiens 25Jan2025 5 13 2.50
21 Bellinzona 08Jan2025 6 31 5.38
22 Geneva 04Jan2025 6 23 3.90
23 Overall 01Jan2025 6 600 100.00
Recruitment of patients by country
Center First participant in Months accruing Participants accrued Accrual rate (per month)
2 Switzerland 01.01.2025 6 558 93.00
3 Germany 23.01.2025 5 10 1.90
4 Italy 18.01.2025 5 15 2.76
5 France 25.01.2025 5 17 3.27
6 Overall 01.01.2025 6 600 100.00

So far 58 patients had at least one SAE since the start of the study. This represents 10% of patients.

Patients with ≥1 SAE per Country
Country Patients
with ≥1 SAE		 Total
Patients		 %
with SAE
France 3 17 17.6
Germany 1 10 10.0
Switzerland 53 558 9.5
Italy 1 15 6.7
SAEs by Event Type and Seriousness
Event Name Disability Hospitalization Life-threatening Other
Bone fracture 1 7 1 4
Cardiovascular event 1 8 1 2
Genital infection 0 6 1 3
Gout attack 1 9 2 4
Ketoacidosis 0 5 0 2
New onset diabetes mellitus 3 8 0 1
Urinary tract infection 1 4 5 0
Patient dropout per country
Patient Dropouts per City and Country
Country Total Patients Dropouts % Dropouts
France 17 3 17.6
Switzerland 558 64 11.5
Germany 10 1 10.0
Italy 15 0 0.0
Dropout reason summary
Dropout Reasons Summary
Reason Count % of
All Dropouts
Adverse event 22 32.4
Withdrawal of consent 17 25.0
Lost to follow-up 16 23.5
Investigator decision 7 10.3
Protocol deviation 4 5.9
Death 2 2.9
Overview of query status per site
Days to close query per site
Missing data per form, visit and site
Missing data rates per form
Form Missing (%)
Labs 34.5
AE 29.3
Vitals 24.2
ConMeds 19.9
Demographics 14.6